姓 名：徐海洋
徐海洋，教授，博士生导师，98858vip威尼斯下载“百人计划”获得者，长期从事植物次生代谢和植物合成生物学领域的研究。2014年1月毕业于中国科学院遗传与发育生物学研究所，并获得遗传学博士学位。2014年3月起，在美国密歇根大学安娜堡分校从事博士后研究工作，并于2018年10月入职98858vip威尼斯下载。近年来主持国家自然科学基金面上项目1项和科技部重点研发计划子课题各2项，川渝合作项目等省部级课题3项。以通讯/一作在Current Biology、Molecular Plant、New Phytologist、Metabolic Engineering、Plant Physiology等国际知名学术杂志发表多篇重要论文。目前担任Molecular Plant、Metabolic Engineering、Horticulture Research等学术期刊审稿人。
研究领域
植物天然产物代谢和调控机制解析及植物合成生物学。
综合利用基因组学，转录组学和代谢组学技术等现代组学技术，解析具有重要经济价值和药用价值的植物天然产物的合成通路及其调控机制，并进一步通过合成生物学手段和技术，以番茄果实和腺体腺毛为植物底盘细胞，探索其在合成生物学上的应用。
主要成果
（#Corresponding author/通讯作者）
Chen J, Tan J, Duan X, Wang Y, Wen J, Li W, Li Z, Wang G, Xu H#. 2023. Plastidial engineering with coupled farnesyl diphosphate pool reconstitution and enhancement for sesquiterpene biosynthesis in tomato fruit. Metab Eng 77: 41-52.
Wang C, Wang Y, Chen J, Liu L, Yang M, Li Z, Wang C, Pichersky E, Xu H#. 2022. Synthesis of 4-methylvaleric acid, a precursor of pogostone, involves a 2-isobutylmalate synthase related to 2-isopropylmalate synthase of leucine biosynthesis. New Phytol 235(3): 1129-1145.
Wang Y, Wen J, Liu L, Chen J, Wang C, Li Z, Wang G, Pichersky E, Xu H#. 2022. Engineering of tomato type VI glandular trichomes for trans-chrysanthemic acid biosynthesis, the acid moiety of natural pyrethrin insecticides. Metab Eng 72: 188-199.
Chen J, Liu L, Wang Y, Li Z, Wang G, Kraus GA, Pichersky E, Xu H#. 2021. Characterization of a Cytosolic Acyl-Activating Enzyme Catalyzing the Formation of 4-Methylvaleryl-CoA for Pogostone Biosynthesis in Pogostemon Cablin. Plant Cell Physiol 62(10): 1556-1571.
Li W, Lybrand DB, Xu H, Zhou F, Last RL, Pichersky E. 2020. A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate. Front Plant Sci 11: 482.
Lybrand DB, Xu HY, Last RL, Pichersky E. 2020. How Plants Synthesize Pyrethrins: Safe and Biodegradable Insecticides. Trends in Plant Science 25(12): 1240-1251.
Xu H, Li W, Schilmiller AL, van Eekelen H, de Vos RCH, Jongsma MA, Pichersky E. 2019. Pyrethric acid of natural pyrethrin insecticide: complete pathway elucidation and reconstitution in Nicotiana benthamiana. New Phytol 223(2): 751-765.
Xu H, Lybrand D, Bennewitz S, Tissier A, Last RL, Pichersky E. 2018. Production of trans-chrysanthemic acid, the monoterpene acid moiety of natural pyrethrin insecticides, in tomato fruit. Metab Eng 47: 271-278.
Xu H, Moghe GD, Wiegert-Rininger K, Schilmiller AL, Barry CS, Last RL, Pichersky E. 2018. Coexpression Analysis Identifies Two Oxidoreductases Involved in the Biosynthesis of the Monoterpene Acid Moiety of Natural Pyrethrin Insecticides in Tanacetum cinerariifolium. Plant Physiol 176(1): 524-537.
Xu HY*, Bohman B*, Wong DCJ, Rodriguez-Delgado C, Scaffidi A, Flematti GR, Phillips RD, Pichersky E, Peakall R. 2017. Complex Sexual Deception in an Orchid Is Achieved by Co-opting Two Independent Biosynthetic Pathways for Pollinator Attraction. Current Biology 27(13): 1867-1877.
Xu H, Zhang F, Liu B, Huhman DV, Sumner LW, Dixon RA, Wang G. 2013. Characterization of the formation of branched short-chain fatty acid:CoAs for bitter acid biosynthesis in hop glandular trichomes. Mol Plant 6(4): 1301-1317.
发明专利
1.表达反式菊酸的联合表达载体及其在调控番茄VI型腺体腺毛合成反式菊酸中的应用。徐海洋，王莹，陈静，文静。申请号：202111432865.1 （进入实质审核阶段）
2.新型短侧链脂肪酸CoA连接酶及其在制备广藿香酮中的应用。徐海洋，陈静。申请号：202110577279X（已授权）
3.一种可提升广藿香醇合成量的融合基因及方法。徐海洋，陈静，王莹，谭静。申请号：
202211273337.0（进入实质审查阶段）
